I'm 28 years old, taking medications for high blood pressure (lokren, tertensif and caldyum). I would like to start trying for a baby - should I stop trying?
The basis for information about each drug is a document issued by the manufacturer - it is available in two versions: the shortened version under the name "patient information leaflet" and the full version for the physician under the name "Summary of Product Characteristics". For Lokren see section 4.6. Pregnancy and lactation, the manufacturer of the drug wrote the following information in the Summary of Product Characteristics document, and I quote: “Betaxolol hydrochloride was not teratogenic in animal studies. To date, no teratogenic effects of betaxolol hydrochloride in humans have been reported. Beta-blockers reduce the flow across the placenta, which can cause intrauterine fetal death, premature and premature delivery. In addition, adverse effects (especially hypoglycaemia and bradycardia) may occur in the fetus. The neonatal period: In newborns of mothers treated with beta-blockers, the effects of these drugs last for several days after delivery; there is an increased risk of cardiac and pulmonary complications in newborns in the postnatal period. In case of heart failure, the newborn should be transferred to the intensive care unit (see section 4.9), administration of plasma expanders should be avoided (risk of acute pulmonary edema). Bradycardia, respiratory distress and hypoglycaemia have also been reported in the neonate. According to the above-mentioned symptoms, close medical supervision of the newborn baby is recommended in a specialized center (monitoring of heart rate and blood glucose levels during the first 3 to 5 days of life. Therefore, the use of betaxalol hydrochloride during pregnancy is not recommended, unless the therapeutic benefits outweigh the possible benefits. risk to the newborn. "The content of the document" Summary of product characteristics "for the drug called Kaldyum is available at http://www.egis.pl/fileadmin/user_upload/leki_nowe/Kaldyum_CPL.pdf In section 4.6 of this document," pregnancy and lactation " we read, and I quote: "due to the reduction of gastrointestinal motility associated with pregnancy, potassium preparations in solid pharmaceutical forms for oral administration shouldbe administered to pregnant women with caution and only in strictly justified cases. Kaldyum, being an oral preparation of potassium in a solid pharmaceutical form, quickly releases a large number of micropellets from its original pharmaceutical form, which allows them to be evenly mixed with the food content. This property of the preparation seems to limit the above-mentioned risks, mainly associated with the use of solid pharmaceutical forms which, during passage through the gastrointestinal tract, retain their large dimensions for a long time (e.g. matrix tablets) and due to the point release of significant amounts of the active substance and (or) the mechanical action of the unchanged pharmaceutical form may have adverse effects on the gastrointestinal tract. The correct concentration of K + ions in human milk is about 13 mmol / l. Since orally delivered potassium contributes to the building and maintenance of this electrolyte in the body, it does not appear that Kaldyum, when used by nursing women in accordance with its indications and recommended dosage, could have any significant effect on the concentration of potassium in milk ”. Regarding Tertensif SR, the patient information leaflet contains the following statement, and I quote: “It is not recommended to use Tertensif SR during pregnancy. If you are pregnant or planning to become pregnant, please inform your doctor. In this case, alternative treatment should be started as soon as possible. The active substance is excreted in the milk. Breastfeeding is not recommended while using the drug ”. The full content of the leaflet is available on the Internet at http://leki-informacje.pl/lek/ulotka/1271,tertensif-sr.html Reading these documents shows that Tertensif SR should not be used in pregnant women, which means usually with the possibility of discontinuing the potassium preparation, i.e. Kaldyum. On the other hand, the use of Lokren, I encourage you to discuss the problem again with your attending physician. Regards, Dr. n.med. Krystyna Knypl
Remember that our expert's answer is informative and will not replace a visit to the doctor.
Krystyna KnyplInternist, hypertensiologist, editor-in-chief of "Gazeta dla Lekarzy".
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