- Chromogranin A (CgA) - when to do the test?
- Chromogranin A (CgA) - what is the test and how much does it cost?
- Chromogranina A(CgA) - norms
- Chromogranin A (CgA) - how to interpret the test results?
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Chromogranin A, CgA for short, is a protein from the granin family, synthesized and stored in many neuroendocrine tissues, e.g. pancreas, adrenal glands, and neurons. In addition, chromogranin A together with chromogranin B and C are produced in the granules of secretory cells of neuroendocrine tumors. For this reason, chromogranin A is used as a sensitive but nonspecific tumor marker as it can be secreted by both he althy and cancer cells.
Chromogranin A , abbreviatedCgAis a protein from the granine family, synthesized and accumulated in many tissues of a neuroendocrine nature, e.g. pancreas, adrenal glands, neurons. In addition, chromogranin A together with chromogranin B and C are produced in the granules of secretory cells of neuroendocrine tumors. For this reason, chromogranin A is used as a sensitive but nonspecific tumor marker as it can be secreted by both he althy and cancer cells.
Chromogranin A (CgA) - when to do the test?
Chromogranin A testing is ordered when neuroendocrine tumors are suspected, which may be manifested by:
- with quick breathing and heartbeat
- difficulty breathing
- dilated pupils
- a headache
- paroxysmal facial redness
- shaking hands
After a tumor has been diagnosed, the determination of the level of chromogranin A may be used to assess the effectiveness of treatment. If your level drops, you will heal successfully.
Chromogranin A (CgA) - what is the test and how much does it cost?
The test of chromogranin A is performed on an empty stomach from venous blood taken from the elbow bend. This is very important as the concentration of chromogranin A increases after a meal. After collection in the laboratory using immunoenzymatic methods, e.g. ELISA, its level in the sample is determined.
A blood test in a commercial laboratory costs about PLN 140-180.
Additionally, the determination of chromogranin A in the collected tissue specimens is used in immunohistochemical tests to determine the stage of neuroendocrine tumors.
Chromogranina A(CgA) - norms
The norms for chromogranin A in the blood depend on the research method used and the monoclonal antibodies used. In addition, standards can be expressed in different units. Therefore, if chromogranin A is tested several times in the same person, e.g. to monitor treatment, the test should be performed in the same laboratory.
Examples of standards for chromogranin A are:
- 1.6-5.6 ng / ml
- 20-100 µg / l
- <40 AU
- <4 nmol/l
Chromogranin A (CgA) - how to interpret the test results?
The increase in chromogranin A concentration is observed in:
- pancreatic cancer
- prostate cancer
- liver cancer
- small cell lung cancer
Additionally, very high concentrations of chromogranin A in the presence of a tumor may indicate high malignancy and poor prognosis.
The result of the chromogranin A test is best interpreted together with other tests and the clinical picture, because both too high and normal levels do not exclude a tumor.
In addition, a slight increase in chromogranin A is observed in non-cancerous states:
- Crohn's disease
- Parkinson's disease
- untreated hypertension
- circulatory failure
- kidney failure
- prostate enlargement
- rheumatoid arthritis
- atrophic gastritis
It is also worth knowing that some drugs affect the concentration of chromogranin A:
- proton pump inhibitors
- H2 receptor blockers