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Nifuroxazide is classified as an antibacterial drug. It can be used in the form of an oral suspension (syrup) or in the form of tablets. The syrup can only be obtained with a prescription, while the tablets can be purchased without a prescription. Check what is the action of this substance.

Nifuroxazide - ingredients

Nifuroxazide(4-hydroxybenzoic acid 2 - [(5-nitro-2-furanyl) methylene] hydrazide) - is an organic chemical compound with chemotherapeutic activity belonging to the nitrofuran family, that is, compounds with furan in their structure with an attached nitro group.

Tablet- contains 200 mg of nifuroxazide; excipients: potato starch, povidone, magnesium stearate and an Opadry II coating consisting of polyvinyl alcohol, macrogol 3350, quinoline yellow, lake (E 104); talc, titanium dioxide (E 171), sunset yellow, lake (E 110); indigo carmine lake (E 132).

Syrup- contains 220 mg / 5 ml of nifuroxazide suspension; 4.00 g vehiculum 100.00 g

Nifuroxazide - action

Nifuroxazide has antibacterial activityagainst most bacteria that cause intestinal infections and has anti-cancer activity towards colorectal and breast cancer.

Indications for its use are acute and chronic bacterial diarrhea and other diseases in the course of diarrhea.

The drug works primarily against bacteria:

  • Gram-positive
  • Staphylococcus and Streptococcus seeds
  • Gram-negative bacilli Yersinia spp., Escherichia spp., Enterobacter spp., Klebsiella spp. Salmonella spp., Shigella spp.

The detailed mechanism of action of the drug has not been known yet. However, nifuroxazide is expected to act locally by inhibiting the activity of bacterial dehydrogenases and enzymes involved in their protein synthesis. Aldehyde dehydrogenase (ALDH) is responsible for the bioactivation of this drug.

Nifuroxazide has been found to have a strong inhibitory effect (inhibitor) of the Janus kinase 2 and transcription factor 3 (JAK2 / STAT3) pathways. It also has a direct effect on oxidative stress and cell apoptosis. It does not affect the microbiological balance of the digestive tract.

Absorbsmoving quickly, only in the intestinal lumen, does not cause a general effect. It is quickly excreted from the patient's body.

Nifuroxazide - application

Nifuroxazide is used:

  • in the treatment of acute and chronic diarrhea caused by bacterial infections, including diarrhea in children and infants
  • to treat other diseases associated with diarrhea such as acute food poisoning
  • in the treatment of colorectal cancer
  • in the treatment of breast cancer
  • in post-transplant diseases directed against the host
  • in nephroprotection in the case of diabetes.

Nifuroxazide - indications

It is recommended to use the drug in acute or chronic diarrhea in the course of bacterial infections of the gastrointestinal tract or in the course of other diseases affecting the intestines.

Nifuroxazide - contraindications

The contraindication to the use of nifuroxazide is:

  • allergy to nifuroxazide
  • allergy to 5-nitrofuran derivatives
  • allergic to any module mentioned in the composition of the drug.

Nifuroxazide - dosage

The drug should be used as described in the patient information leaflet or according to specific guidelines and recommendations of a doctor or pharmacist. Check with your doctor or pharmacist if you are not sure.

Nifuroxazide - precautions

When using nifuroxazide , remember to properly hydrate the bodywith fluids and electrolytes. The drug should be taken in accordance with a strict, easily digestible diet.

It is recommended during the diet to omit foods that cause excessive secretion of digestive juices. Such dishes include spicy and fatty products, smoked meats, alcohol, dried fruit, nuts and silage.

If your diarrhea becomes severe or persistent after taking this medicine for 2 or 3 days, contact your doctor immediately.

If you miss a dose, take it as soon as possible. Do not use a double dose to make up for the missed dose.

Nifuroxazide - side effects

Nifuroxazide may cause an allergic reaction.Reported drug-induced ailments include:

  • allergic skin reaction
  • hives
  • rash
  • stomach pains
  • nausea
  • diarrhea intensification
  • sleepiness
  • coordination disorders and psychophysical fitness impairing the ability to drive or use machines.

Nifuroxazide- interactions with other drugs and diseases

In order to avoid undesirable ailments, inform your doctor or pharmacist about all medications that are currently or recently used, as well as about medications that the patient is going to use.

You should also inform your doctor about your current he alth condition, about any diseases or additional ailments you are struggling with.

Nifuroxazide and pregnancy and breastfeeding

Before taking the drug, inform your doctor if you are pregnant or breastfeeding. The use of nifuroxazide during pregnancy and breastfeeding is generally not recommended.

Nifuroxazide - drug storage

The drug should be stored in a suitable place that is invisible and inaccessible to children. Store in a dry place below 25 ° C in the original packaging.

The drug should not be used after the expiry date stated on the package. The expiry date refers to the last day of that month.

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