Pepsin is a digestive enzyme found in the stomach. The active form of pepsinogen secreted by the stomach is responsible for digestion, and in medicine it is used in the treatment of gastritis, ischemia and even lack of appetite. What should I know about pepsin?

Pepsinwas discovered in the 19th century by Theodor Schwann. It is an active form of pepsinogen, a proenzyme (also: zymogen) secreted by gastric glandular cells. The production of an inactive form of the enzyme by the organ prevents its damage and allows for safe activation in the place where pepsin is needed.

How does pepsin work?

Under the influence of the acidic environment of the stomach, irreversible hydrolysis of peptide bonds or auto-activation takes place, which results in the formation of pepsin. It initiates the process of protein digestion and is a component of gastric juice. As a result, proteins are broken down into peptides, which are easier to digest and can be further digested by pancreatic enzymes.

Pepsin secretion is increased after eating a meal or by acidifying the mucosa.

Pepsin not only as a medicine

The use of pepsin in pharmacological treatment, e.g. in a specially prepared in a pharmacy Mixtura Pepsini preparation, may help with ailments such as gastritis, ischemia and anorexia.

It is a great solution also in the case of pancreatitis and stimulates the secretion of bile.

It also supports the absorption of vitamins. It is also used in the production of food, such as the production of supplements, snacks and haberdashery.

Disorders in pepsin secretion

Any disturbance in the functioning of pepsin secretion can have serious consequences. The most common symptoms are:

  • indigestion,
  • stomach pains,
  • gas and gas,
  • nutrient deficiency,
  • and even leaky gut syndrome.

These can be due to poor nutrition, contributing to nutrient deficiencies, long-term antibiotic treatment, and consuming too much fluid with meals. Taking pepsin can be a solution to these ailments.

If pepsin enters other parts of the gastrointestinal tract, it can cause gastro-oesophageal reflux disease. She is leadingdamage to the mucosa and larynx, which is a potentially carcinogenic phenomenon.

Taking supplements containing pepsin may, however, have side effects, manifested by ailments from the digestive system. These include:

  • diarrhea
  • nausea
  • rash
  • stomach ache

Treatment should be consulted with a gastroenterology doctor.

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Category:

Gastrology