What is the probability of my daughter (2.5 years) developing bronchial asthma if my husband suffered from it - her dad and her great-grandmother (and my husband's grandmother from my husband's dad's side)?
Bronchial asthma arises as a result of the interaction of unfavorable environmental factors and genetic predisposition. It has long been known that there are families with more than one person, but asthma is not passed down from generation to generation in a manner entirely typical of hereditary diseases.
Although there is extensive research into the genetic factors involved in asthma, no 'universal' gene or set of genes responsible for its development has yet been discovered. Therefore, at the present stage of knowledge, it is not possible to perform a genetic test on a he althy person in order to accurately determine their risk of developing the disease in the future.
Based on empirical data, it is estimated that if one of the parents has asthma (with no tendency to atopic changes, e.g. atopic dermatitis), the risk of developing the disease is approximately 5%. Some clinical trials have suggested that the risk is higher if the mother is sick and lower if the child's father is sick. If one of the parents has asthma in the context of atopic lesions, the risk of developing the disease is much higher and may be as high as 50%.
Remember that our expert's answer is informative and will not replace a visit to the doctor.
Krystyna SpodarKrystyna Spodar - specialist in the field of clinical genetics at NZOZ Genomed, ul. Ponczowa 12, 02-971 Warsaw, www.nzoz.genomed.pl, e-mail: [email protected]
The expert answers questions about genetic diseases and congenital malformations, inheritance, and prenatal diagnosis.
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