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In my husband's family there was a large number of cases of cancer. On my mother's side, my grandmother had breast cancer, her 2 daughters had cervical cancer (it's not hereditary, I guess?), My father's grandfather suffered from lung cancer, my aunt and great-grandfather had stomach cancer, I don't know how they ate, neither I can tell if the diet contributed to this. I am very scared because it is commonly said that cancer is a hereditary disease and with a large number of cases, gene mutations certainly occur, although genetic tests have been negative. My husband had a colonoscopy and gastroscopy done, no changes showed. I try to follow a he althy diet, but anxiety accompanies me every day. What is the likelihood of my husband getting sick and what can we do to reduce the risk?

A he althy lifestyle, proper diet and proper physical activity are extremely important as they reduce the risk of cancer. However, in order to accurately assess the risk of cancer in you and your husband, it is necessary to consult a specialist clinical geneticist with experience in the field of oncogenetics.

For obvious reasons, the Internet is not the right place for individual genetic counseling. It is very important to collect the family history correctly, based on the available medical documentation. The age of the relatives' onset, the result of the histopathological examination, and the exact location of the neoplasm are important.

As it appears from your letter - genetic tests were performed on you, your husband or people who were ill in the family. Which genes were studied and to what extent - i.e. which exons? What does "normal colonoscopy" mean in my husband - were there any polyps found, and if so, what was their histopathological picture?

As can be seen from the above, in order to establish for you and your husband appropriate recommendations regarding preventive examinations and possible indications for genetic tests, it is advisable to visit the Genetic Clinic. I invite you.

Remember that our expert's answer is informative and will not replace a visit to the doctor.

Krystyna Spodar

Krystyna Spodar - specialist in the field of clinical genetics at NZOZGenomed, ul. Ponczowa 12, 02-971 Warsaw, www.nzoz.genomed.pl, e-mail: [email protected]

The expert answers questions about genetic diseases and congenital malformations, inheritance, and prenatal diagnosis.

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