Nitrendipine is a multifunctional organic chemical compound that is a derivative of dihydropyridine. It has found application in the treatment of mild to moderate hypertension. What does nitrendipine help for? What side effects may occur after using it? Check it out!

Nitrendipine: what is it?

Nitrendipine is a multifunctional organic chemical compoundwhich is a derivative of dihydropyridine. The drug was patented in 1971 and introduced to the pharmaceutical market in 1985. It belongs to antihypertensive drugs, i.e.lowering blood pressure . Nitrendipine is acalcium antagonistused to block calcium channels. It helps to reduce tension and dilate blood vessels. It is available by prescription in the form of oral tablets.

Nitrendipine: composition

Tablet ( Nitresan10 mg): The active ingredient is nitrendipine.Excipientsto:

  • lactose monohydrate,
  • corn starch,
  • microcrystalline cellulose,
  • povidone K-25,
  • docusate sodium,
  • magnesium stearate.

Nitrendipine: action

Nitrendipineacts on free calcium channels.The nitrendipine molecule attaches to calcium channels in an inactivated state, thereby blocking the influx of calcium ions into the cell. It has a strong effect on smooth muscle cells in the vascular wall with a minimal effect on myocardial cells.The drug reduces the resistance of blood vessels and lowers blood pressure.

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Nitrendipine: application

Nitrendipine has been used in the treatment of mild to moderate hypertension.

Nitrendipine: indications

It is recommended to use the drug to dilate blood vessels. Nitrendipine is aneffective antihypertensive agentand differs from other calcium channel blockers in that it does not reduce the glomerular filtration rate and is mildly natriuretic (regulator of sodium-water balance) rather than sodium retention.

Nitrendipine: contraindications

Not to be usednitrendipineif you are allergic to nitrendipine or any of the modules listed in the drug composition if you have a narrowed aortic valve or have had a heart attack in the last 4 weeks.

Nitrendipine: dosage

The drug should beused as described in the patient information leafletor according to specific guidelines and recommendations of a doctor or pharmacist. Check with your doctor or pharmacist if you are not sure.

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Nitrendipine: precautions

When taking nitrendipine, special care should be taken in patients suffering from impaired liver function, as the effect of nitrendipine may be increased as a result of a decrease in the efficiency of the metabolism of the substance in the liver.Caution should also be exercised in patients with decompensated heart failure . Grapefruit juice inhibits the metabolism of nitrendipine. Therefore, consumption of grapefruit juice during treatment is not recommended.

Nitrendipine: side effects

Nitrendipine may cause the appearance of:

  • headache,
  • swollen ankles and legs,
  • angina attacks (chest pain),
  • vasodilation,
  • aggravation of angina attacks,
  • redness of the facial skin,
  • fatigue,
  • transient loss of consciousness (fainting),
  • restlessness,
  • vision abnormal,
  • peripheral vertigo,
  • low blood pressure,
  • shortness of breath,
  • nausea,
  • vomiting,
  • stomach ache,
  • diarrhea,
  • constipation,
  • need to urinate more often (polyuria),
  • weight gain,
  • excessive sweating.

Nitrendipine: interactions with other drugs and diseases

In order to avoid undesirable ailments , inform your doctor or pharmacist about all medications you are takingor recently, and about medications you intend to use. You should also inform your doctor about your current he alth condition, about any diseases or additional conditions you are struggling with. Usually, the simultaneous use of drugs such as blood pressure lowering drugs and water tablets (diuretics) or other drugs will affect the way the blood works.nitrendipine.

Nitrendipine: pregnancy and breastfeeding

Before taking the drug,tell your doctor if you are pregnant or breastfeeding.The use of nitrendipine during pregnancy and breastfeeding is generally not recommended.

Nitrendipine: drug storage

The drugshould be stored in a suitable place that is out of the sight and reach of children.Store in a dry place below 25 ° C in the original packaging. The drug should not be used after the expiry date stated on the package. The expiry date refers to the last day of that month.

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