Chewing tobacco, gum with nicotine and sucking nicotine lozenges stimulate the formation of squamous cell carcinoma of the mouth - one of the most common and deadliest in the world.
Research on the influence of the FOXM1 gene on the development of cancer cells was carried out by a group of scientists from Queen Mary University in London, led by Professor Muy-Teck Teh. Preliminary studies have shown that the presence of nicotine in the oral cavity activates thecarcinogenicabilities of this gene and leads to the development of oral cancer cells.
Nicotineis now considered a safe and non-cancercancersubstance that is often used in tobacco replacement therapies despite increasing numbers of evidence of the anti-apoptotic effect it has on the cells of the mouth. Chewing gums and lozenges containing nicotine and nicotine patches cause a high concentration of nicotine in the mouth and on the skin. It is equally dangerous to serve drinks containing nicotine. The above studies show that nicotine directly influences the activation of the carcinogenic capacity of the FOXM1 gene, therefore the use of nicotine in tobacco replacement therapies should be reconsidered.
Tobacco, also the "therapeutic" tobacco contained in chewing gums, lozenges and betel pepper, are the main factors stimulating the development of squamous cell cancer. It is the sixth most common cancer in the world. The average mortality rate over the five years from its occurrence is very high (around 50%) and has not decreased over the past 50 years. The main reason for this situation is the lack of effective diagnostic and prognostic methods that could provide adequate treatment methods in the early stage of cancer development. Treatment often requires complicated and risky surgical procedures.