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Nandrolone is a steroid drug that is used, inter alia, in in the course of osteoporosis. However, it is best known as a doping agent. Nandrolone primarily strengthens muscle mass. Besides, it makes it possible to train without pain. What else does nandrolone do? What are the side effects of its use?

Nandrolonebelongs to the group of steroid hormones, which has been used not only in medicine, but also as a doping agent. The two most common forms of nandrolone are nandrolone decanoate and nandrolone phenylpropionate, but the former is the best known.

Nandrolone as a drug - action and indications for use

Nandrolone incl. affects the growth of skeletal muscles and increases bone mineral density. For the latter reason, it has found application in the treatment of osteoporosis in postmenopausal women. In addition, it is used in the analgesic treatment of selected cases of metastatic breast cancer in women.

Nandrolone is chemically similar to testosterone, but its anabolic effect is stronger than that of testosterone.

Nandrolone is also used to treat protein deficiency during convalescence, in severe pre- and postoperative conditions, after burns, fractures, radiotherapy, in debilitating diseases, malnutrition, in the treatment of bedsores, during therapy with drugs such as cytostatics or corticosteroids. Less frequently it is used in ophthalmology in the form of eye drops.

Nandrolone as a doping agent

According to a study by scientists from Maastricht University in the Netherlands, which was attended by 16 experienced bodybuilders aged 19-44 years, nandrolone contributed to an increase in body weight by 2.2 kg in 8 weeks, lean mass by 2.6 kg (muscle) and total body water by 1.4 kg. There were no changes in the amount of adipose tissue, muscle hydration, bone mass and density. Bodybuilders received 200 mg of nandrolone decanoate per week or a placebo for 8 weeks.

- Nandrolone is a typical steroid that primarily strengthens muscle mass - explains prof. Smorawiński, chairman of the Commission Against Doping in Sport.

In turn, the research of specialists from the Netherlands Center for Doping Affairs shows that nandrolone (in a dose of 200 mg) within 8 weeks allowed 16 men to gain more than 3.1 kg of lean body mass (including 2.03 kg in body and 1.08 kg on legs) .² In addition, there was a decrease in the amount of fat tissue on the legs by 1.9%.

Nandrolone retains water in the joints, so athletes who use it - usually with shoulder or knee pain - can train without feeling any pain. However, it comes back after you stop taking the drug.

Nandrolone comes in the form of a solution for injection into the muscles. The maximum concentration will occur after two or three days. There are known cases of the presence of a measurable concentration in an athlete after the use of eye drops containing nandrolone, used to rebuild the cornea. It practically does not work after oral administration, because orally it is very poorly absorbed.

What is Nandrolone? Explains prof. Jerzy Smorawiński, chairman of the Commission Against Doping in Sport

Source: x-news.pl/TVN24

Nandrolone - side effects

Nandrolone accelerates the reconstruction of muscle mass, the regeneration process, but if taken for a longer period and not in accordance with the recommendations, it has many side effects - says Dr. Łukasz Luboiński, traumatologist orthopedist at the Carolina Medical Center. - It can lead to personality disorders and emotional lability - adds the expert. Besides, the side effects of nandrolone are:

Nandrolone, taken over a long period of time and in violation of the recommendations, has many side effects - says Dr. Łukasz Luboiński, an orthopedic traumatologist at the Carolina Medical Center.

  • high blood pressure
  • hepatic impairment
  • blood coagulation disorders
  • acne
  • increased fat accumulation
  • in men: decreased libido, erectile dysfunction, inhibition of spermatogenesis (sperm production), testicular function, gynecomastia (male breast enlargement)
  • in women: menstrual disorders, inhibition of ovulation, deepening of the tone of the voice

Side effects of nandrolone - Dr. Łukasz Luboiński, orthopedist traumatologist at Carolina Medical Center

Source: x-news.pl/TVN24

Nandrolone - contraindications

Nandrolone is detected in the urine a few months (even six months) after taking it.

  • pregnancy
  • breastfeeding
  • cancer

It should be used with caution in patients with heart failure, renal dysfunction, arterial hypertension, migraine, diabetes,hepatic impairment. Particular care should be taken in children and adolescents during adolescence as it may disrupt this process.

Sources:

1. Bodybuilders' body composition: effect of nandrolone decanoate - http://www.ncbi.nlm.nih.gov/pubmed/15076791

2. Body composition and anthropometry in bodybuilders: regional changes due to nandrolone decanoate administration - http://www.ncbi.nlm.nih.gov/pubmed/11354529

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