People with diabetes are 2-3 times more prone to coronary heart disease, which in this group of patients carries an additional 2-4 times higher risk of mortality. Therefore, a patient with diabetes and coronary heart disease is a patient who requires an extremely careful therapeutic approach.

Diabeteshas a direct impact on complications in the cardiovascular system and the development of heart disease ,such ascoronary heart disease . And once diabetics become ill, they are more difficult to treat because of comorbidities, pathophysiological changes in the coronary and circulatory system, and other complications. That is why it is so important to choose the right treatment.Resolute Integrity- zotarolimus-releasing coronary stent - is the first Food and Drug Administration (FDA) approved solution for use in diabetic patients.

Diabetes and coronary artery disease

Estimates show that there are 285 million people with diabetes in the world today. In Poland, it is about 2.67 million people.Diabetesis especially dangerous for the heart and blood vessels, increasesthe risk of coronary artery diseaseand heart failure. It is known from studies that almost half of diabetics have complex risk factors, such as, for example, branching of the coronary vessels, renal failure, thrombotic changes, etc. Diabetes can cause vascular complications in which endothelial dysfunction such as, for example, narrowing and dilating blood vessels or problems with blood clotting, which makes the atherosclerotic lesions more diffuse. - A person suffering from diabetes should use intensive glycemic control and prophylactically use pharmacotherapy, early cardiological diagnostics is also important, which will allow for early treatment and prevent many complications and the development of the disease - says Andrzej Bauman, president of the Board of the Polish Diabetes Association.

Cardiovascular system and diabetes

Blood vessels in diabetic patients are smaller and have a more demanding, tortuous anatomical structure. Diabetes also increases the risk of restenosis (re-narrowing of the artery after its restoration) and stent thrombosis. These factors can lead to an increased incidence of complications aftertreatments and long-term he alth risks. - A patient with diabetes is a patient requiring special care due to accompanying diseases and conditions related to the underlying disease. Diabetics tend to have narrower, tortuous arteries, more diffuse atherosclerotic lesions, and elevated blood sugar levels. All these factors increase the risk of postoperative complications. Many such patients undergo surgical treatment of coronary artery disease, which is more invasive, requires a longer stay in the hospital and a longer recovery time compared to the stent insertion procedure, says Prof. Adam Witkowski from the Institute of Cardiology in Warsaw

Resolute Integrity in the treatment of coronary heart disease

Resolute Integrity - Drug eluting stent (DES) is used in the minimally invasive procedure - Percutaneous Coronary Intervention (PCI), which is an alternative tosurgical treatment of coronary artery disease . A stent mounted on a balloon catheter is inserted through a puncture, e.g. in the femoral artery. The stent is then directed to the constricted coronary vessel, where it is positioned and expanded with a balloon. The stent is used to open the vessel and restore normal blood flow to the heart. In addition, Resolute Integrity performs another important function: this stent releases a drug that prevents the excessive growth of tissue in the vessels and their re-narrowing (restenosis), which is especially prone to diabetic patients. Its structure is very flexible, which makes it easier to insert it into the coronary artery. This is an important parameter in the case of diabetic patients. The use and effectiveness of the Resolute Integrity stent has been proven in clinical trials (RESOLUTE studies). Literature:

Tan, Meng Hee. From Research to Practice Diabetes and Coronary Heart Disease. Diabetes Spectrum1999; 12: 80-83. http: //journal.diabetes.orghttp: //diabetologiaonline.plhttp: //www.rynekzdrowia.pl

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