Permethrin is a synthetic chemical that belongs to the group of pyrethroids. In 1979, the drug was first registered with the United States Environmental Protection Agency (US EPA). In 1992, in Switzerland, the drug was introduced to the market for dermatological and venereology purposes. It is an insecticide used in the form of gels, medicated shampoos and creams for skin coatings.

Composition of permethrin

Gel(Scabinol):

  • the active substance is permethrin,
  • excipients: ethanol (96%), carbomer 980, trolamine, purified water.

Healing shampoo(Sora Forte):

  • the active substance is permethrin,
  • excipients: sodium lauryl sulfate ethoxylate, cocamidopropyl betaine, coconut oil diethanolamide, isopropyl alcohol, propylene glycol, diazolidinurea, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate, citric acid (E 216) , ethylene glycol distearate, coconut oil monoethanolamide, ethoxylated lauryl alcohol 10, hydrogenated castor oil, ethoxylated lauryl alcohol 2, fragrance, purified water.

Cream(Infectoscab):

  • the active substance is permethrin,
  • excipients: cetostearyl alcohol, emulsifying (type A), liquid paraffin, white petrolatum, sorbic acid, purified water.

Permethrin action

Permethrin in close contact with an insect reveals its insecticidal effect. The mechanism of action of the drug is based on paralysis of the parasite's nervous system by extending the opening time of sodium channels in the cell membrane of the insect's neuron.

Increased influx of sodium ions disrupts the conduction of nerve impulses between the insect's neurons, leading to muscle contraction, paralysis and death.

Permethrin is more toxic to insects as they cannot break down the drug as quickly as humans.

Permethrin use

Permethrin has been used in medicine as an insecticide and antiparasitic agent.

Indications for the use of permethrin

Permethrin is recommended:

  • in combating head lice,
  • in the treatment of scabies caused by human scabies (Sarcoptes scabiei),
  • in defeating insects that transmit malaria and dengue fever.

Contraindications to the use of permethrin

Do not use the drug if you are allergic to permethrin or any module listed in the drug.

Dosage of permethrin

The drug should be used as described in the patient information leaflet or according to specific guidelines and recommendations of a doctor or pharmacist. Check with your doctor or pharmacist if you are not sure.

Usually the permethrin dosing process depends on the course of the disease and the total body surface area.

Precautions

Due to the risk of irritation, avoid contact with the surrounding area:

  • eyes,
  • open wounds,
  • crotch,
  • mucous membranes.

You should not eat the drug as it can cause:

  • sore throat,
  • stomach ache,
  • nausea
  • and vomiting.

When using the drug, you should protect the nose area, as the drug may:

  • irritate the nasal mucosa,
  • cause breathing problems,
  • contribute to headaches and dizziness.

The preparation should not be used in newborns and children under 2 months of age.

Side effects of permethrin

Permethrin can cause allergic reactions. Side effects include:

  • burning sensation of the skin,
  • erythema,
  • pruritus,
  • paresthesia (tingling, numbness),
  • headache,
  • nausea,
  • inflammation of the hair follicle,
  • skin depigmentation
  • and shortness of breath.

Interaction with other drugs and diseases

In order to avoid undesirable ailments, inform your doctor or pharmacist about all medications that are currently or recently used, as well as about medications that the patient is going to use.

You should also inform your doctor about your current he alth condition, about any diseases or additional conditions you are struggling with.

Permethrin and pregnancy and breastfeeding

Before using the drug, inform your doctor about pregnancy or breastfeeding. Usuallyit is not recommended to use the drug in the first trimester of pregnancy and during breastfeeding .

Storing medicine

The drug should be stored in a suitable place that is invisible and inaccessible to children. Store inin a dry place below 25 ° C, in the original packaging.

The drug should not be used after the expiry date stated on the package. The expiry date refers to the last day of that month.

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