Sodium butyrate - it is a s alt of butyric acid, belongs to the group of short-chain fatty acids, which are the main source of energy for colonocytes, i.e. intestinal epithelial cells. It is more stable and has a less unpleasant odor than butyric acid. This compound can be found in small amounts in some foods. It is produced in the large intestine (colon) with the participation of fermentation bacteria. Sodium butyrate can be purchased as capsules or microcapsules over the counter.

Sodium butyrate composition

Capsule(Debutir): the active substance of the drug is sodium butyrate, fully hydrogenated, and palm oil. Excipients: capsule shell (hydroxypropyl methylcellulose), sodium alginate, mono- and diglycerides of fatty acids, titanium dioxide.

Microcapsule(Aliness Sodium Butyrate 550 mg): the active substance of the supplement is sodium butyric acid (sodium butyrate) in the form of enteric microcapsules. Excipients: microcapsule shell (vegetable stearic acid), vege capsule shell (hydroxypropyl methylcellulose).

Sodium butyrate effect

Sodium butyrate is mainly anti-inflammatory. The anti-inflammatory process consists in inhibiting the activity of inflammatory mediators in the intestinal epithelium, and thus inhibiting the activation of NFκB macrophages, which are the most important source of cytokines in the inflammatory process of inflammatory bowel diseases.

This substance has the ability to reduce IL-8 secretion, thus contributing to the blocking of the anti-inflammatory cytokine cascade at the local level.

Sodium butyrate has a trophic effect, accelerates healing and intestinal regeneration. Its functions include inhibiting the activity of histone deacetylase (HDAC), which is an enzyme that packs DNA molecules into tight, compact structures and prevents its expression.

It also stimulates the biosynthesis of mucus in the intestinal epithelium. In addition, its presence in the intestinal lumen allows you to maintain the correct pH, thus protecting the digestive system against the invasion of microorganisms.

Use of sodium butyrate

Sodium butyrate has been used in the treatment of, among others :

  • bowel dysfunction,
  • inflammatory diseases of the gastrointestinal mucosa, such asinflammatory bowel diseases, diarrhea of ​​various origins, flatulence, chronic constipation,
  • disorders of the intestinal flora,
  • short-chain fatty acid deficiencies, in patients after anti-cancer treatment,
  • inflammation of the intestines after radiotherapy,
  • stomach ulcers,
  • intestinal infections and digestive system disorders.

Sodium butyrate indications

It is recommended to use preparations with sodium butyrate in all diseases of the digestive system. Mainly in:

  • inflammatory bowel diseases,
  • in inflammation of the intestinal pouch,
  • in functional disorders of the digestive tract
  • or in acute viral and bacterial infections of the gastrointestinal tract.

Contraindications to the use of sodium butyrate

Do not use the drug if you are allergic to sodium butyrate or to any of the modules listed in the formulation. It is not recommended to use the preparation in children with swallowing disorders or when swallowing capsules is difficult.

Sodium butyrate dosage

The drug should be used as described in the patient information leaflet or according to specific guidelines and recommendations of a doctor or pharmacist. Check with your doctor or pharmacist if you are not sure.

Precautions

Sodium butyrate is not intended for parenteral use and for supplementing the diet in he althy people, without indications for treatment. The preparation should not be used as the only source of food. The drug should be used under the supervision of a doctor.

Sodium butyrate side effects

So far, no side effects of sodium butyrate have been demonstrated. However, caution should be exercised in patients with hypersensitivity to any of the ingredients of the preparation.

Interaction with other drugs and diseases

In order to avoid undesirable ailments, inform your doctor or pharmacist about all medications that are currently or recently used, as well as about medications that the patient is going to use.

You should also inform your doctor about your current he alth condition, about any diseases or additional ailments you are struggling with.

Pregnancy and breastfeeding

Before taking the drug, inform your doctor if you are pregnant or breastfeeding. The use of sodium butyrate during pregnancy and breastfeeding is generally not recommended.

Storing medicine

The drug should be stored in a suitable place that is invisible and inaccessible to children. Store in a dry place at a temperaturebelow 25 ° C, in original packaging.

The drug should not be used after the expiry date stated on the package. The expiry date refers to the last day of that month.

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