An invasive acinar is a form of gestational trophoblastic disease, the essence of which is the abnormal development of the placenta. Invasive moles, together with chorionic carcinoma (chorionic carcinoma) and tumor of the placental site, belongs to the group of trophoblast neoplasms. It infiltrates adjacent tissues and organs, and may also metastasize to other organs (most often the lungs and vagina). What are the causes and symptoms of an invasive mole? What is the treatment?

The acinar invasive , otherwise destructive (Latinmola hydatidosa invasiva destruens ), is a form of gestational trophoblastic disease, i.e. pathological changes in trophoblast - layers of external cells of the chorion (the element of the fetal egg from which the placenta is formed in the future). Together with chorionic cancer (chorionicoma) and tumor of the placental site, it belongs to the group of trophoblast neoplasms.

A synovial invasive birth occurs once in 15,000 pregnancies

There are partial and complete mornings. In their course, the villi (chorion cells) begin to grow excessively, filling the entire uterine cavity. In the case of an invasive acinar, the villi become malignant and begin to grow into the uterine muscle. Then a bloody focus is formed with necrotic changes in the uterus. Invasive molar infiltrates adjacent tissues and organs. It can also metastasize - most often to the lungs and vagina.

Molar invasive - causes

A partial synamus is the result of an egg being fertilized by two sperm.

A complete birth is the result of an egg being fertilized by one or two sperm. However, in this case, all genetic material from the mother is removed and only that from the father remains.

On the other hand, an invasive molar is either formed on the basis of a molar (usually complete), or has an invasive form from the very beginning.

Risk factors for its development include, among others mother's age - under 16 or over 35 and father's age over 45, smoking, hormonal contraception, miscarriages, in-vitro procedures, previous pregnancy, ovulation abnormalities, diet during pregnancy (low in carotene) .

Molar invasive - symptoms

Cheerfulinvasive can be very dynamic with

  • heavy vaginal bleeding
  • bleeding into the abdominal cavity
  • enlarged uterus
  • vomiting

Symptoms most often appear up to the fifth month of pregnancy.

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Membrane invasive - diagnosis

In case of suspicion of an invasive acinar, transvaginal and transabdominal ultrasound is performed. The view of the breakfast area on the ultrasound resembles a "picture of a blizzard".

In addition, blood tests are required to determine the concentration of HCG (chorionic gonadotropin). In the case of cluster sickness it is usually very high (over 20,000 mIU / ml) .

In connection with metastases, lung X-ray examinations and transvaginal ultrasound (transvaginal ultrasound examination of the reproductive system) are performed.

Molar invasive - treatment

Chemostatics are used in the treatment of invasive molar. If the lesion is confined to the uterus, Methotrexate (MTX) is used. If the tumor has developed after childbirth or if metastatic disease is present, multi-drug therapy is used.

If the woman is not planning to become pregnant, the doctor may decide to have a hysterectomy (removal of the uterus).

Molar invasive - important post-treatment control

Follow-up is required for 10 years after treatment - clinical examinations are carried out, HCG levels are measured and the lungs are x-rayed, with HCG measured first every 2 weeks for 3 months after the end of treatment, and then every 2 months every 2 months. half a year, and then every six months until the end of life. A gynecological examination is performed with each HCG determination. Lung X-ray, on the other hand, is performed every year.

In addition, the woman cannot become pregnant 2 years after the end of treatment.

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Pregnancy